Fluid Resuscitation Physiological Responses in Hemorrhaged Rats
نویسندگان
چکیده
منابع مشابه
Optimal Dose of Hypertonic Saline/Dextran in Hemorrhaged Swine Originally scheduled for publication in the Combat Fluid Resuscitation Supplement*
Background: Hypertonic saline/dextran (HSD) fluid resuscitation has been demonstrated to be effective in alleviating the adverse effects of hemorrhagic hypotension. The optimal dose of HSD has not been defined. Methods: The comparative effectiveness of various dosages of HSD for the treatment of severe hemorrhage was investigated in conscious swine bled 46 mL/kg over 15 minutes, a lethal proced...
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N G-nitro-l-arginine methyl ester (l-NAME; 250 μg/5 μl), an inhibitor of NO synthase, or the vehicle artificial cerebrospinal fluid (aCSF; 5 μl) was administered intracerebroventricularly to conscious rats hemorrhaged (0.7 ml/min) to a 20% volume depletion. Hypotension was maximal 5 min after hemorrhage ended, with compensatory recovery to basal levels 20 min later, regardless of drug treatment...
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Lung ventilation, endotracheal, and intraoesophageal pressures were measured during standard resuscitation of 20 asphyxiated babies born by caesarean section. The most common response to resuscitation was the production of a large positive intraoesphageal pressure. An opening pressure greater than 2.0 kPa was required to expand the lungs of most of these babies. The need for resuscitation was a...
متن کاملPlasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids.
The endothelial glycocalyx plays an essential role in many physiological functions and is damaged after hemorrhage. Fluid resuscitation may further change the glycocalyx after an initial hemorrhage-induced degradation. Plasma levels of syndecan-1 and heparan sulfate have been used as indirect markers for glycocalyx degradation, but the extent to which these measures are representative of the ev...
متن کاملFluid resuscitation in trauma
Appropriate fluid replacement is an essential component of trauma fluid resuscitation. Once he orrhage is controlled, restoration of normovolemia is a priority. In the presence of uncontrolled haemorrhage, aggressive fluid management may be harmful. The crystalloid-colloid debate continues but existing clinical practice is more likely to reflect local biases rather than evidence based medicine....
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.788.9